منابع مشابه
Epigenetics in Ocular Diseases
Epigenetics pertains to heritable alterations in gene expression that do not involve modification of the underlying genomic DNA sequence. Historically, the study of epigenetic mechanisms has focused on DNA methylation and histone modifications, but the concept of epigenetics has been more recently extended to include microRNAs as well. Epigenetic patterning is modified by environmental exposure...
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Background and purpose: Psoriasis is an inflammatory disease with skin and joint manifestations. This disease can be associated with ocular complications and reduce vision and quality of life. The aim of this study was to determine the prevalence and type of ocular involvement in patients with psoriasis to prevent unwanted complications by identifying the disease at the right time. Materials a...
متن کاملEpigenetics in Rare Diseases
By definition, a rare disease is any condition that affects a small percentage of the population. However, the cutoff number for which a disease is considered as rare varies with different regions. In the United States, the cutoff was fewer than 200,000 people [1] and while in Japan, it was fewer than 50,000 [2]. For Europe, rare diseases are life-threatening or chronically debilitating ones in...
متن کاملEpigenetics in rheumatic diseases
With enormous speed novel data are emerging about regulating the expression of the genetically encoded information [1]. This highly complex regulatory network called epigenetics includes acetylation, methylation, phosphorylation, sumoylation and non-coding RNAs (ncRNA), such as miRNA and lncRNAs. Our laboratory is addressing over the past decade inflammatory rheumatic diseases [2], like rheumat...
متن کاملRole of Epigenetics in Biology and Human Diseases
For a long time, scientists have tried to describe disorders just by genetic or environmental factors. However, the role of epigenetics in human diseases has been considered from a half of century ago. In the last decade, this subject has attracted many interests, especially in complicated disorders such as behavior plasticity, memory, cancer, autoimmune disease, and addiction as well as neurod...
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ژورنال
عنوان ژورنال: Current Genomics
سال: 2013
ISSN: 1389-2029
DOI: 10.2174/1389202911314030002